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Androgen Receptor Pathway Inhibitors | Prostate Cancer Foundation These medicines are newer “second-generation” hormone treatments and are FDA-approved for patients with certain states of advanced prostate cancer: Metastatic castration-resistant prostate cancer (mCRPC) You may also hear them referred to as androgen receptor signaling inhibitors (ARSIs) or androgen receptor axis targeted agents (ARATs)
Overview of ARPIs in the Treatment of Prostate Cancer Comprehensive insights on ARPIs (androgen receptor pathway inhibitors) for the treatment of prostate cancer, highlighting what influences treatment decisions and safety profiles of the available APRIs
Addition of New Androgen Receptor Pathway Inhibitors to . . . In recent years, significant changes have occurred in metastatic hormone-sensitive prostate cancer (mHSPC) management, where docetaxel and new androgen receptor pathway inhibitors (ARPI) have been shown to improve overall survival (OS) compared to
Androgen Receptor Pathway Inhibitor Monotherapy in Prostate . . . Background and objective: Androgen receptor pathway inhibitors (ARPIs) as monotherapy are studied increasingly across prostate cancer disease states We aimed to evaluate the safety, oncologic efficacy, and quality of life (QoL) of ARPI monotherapy as compared with ARPI + androgen deprivation therapy (ADT) and ADT alone
Estrogen Patches with ARPIs Found to Be Safe, Effective in . . . Transdermal estradiol patches show similar PSA response to LHRHa when combined with ARPIs in metastatic prostate cancer The STAMPEDE trial indicates tE2 patches offer a favorable safety profile, reducing cardiovascular risks compared to oral estrogen
Androgen receptor pathway inhibitors and drug–drug . . . Androgen receptor pathway inhibitors (ARPIs) have become central to prostate cancer treatment, demonstrating significant effectiveness in both metastatic and non-metastatic contexts
Choice of androgen receptor pathway inhibitors (ARPi) by . . . Given similar efficacy, choice of ARPi requires careful consideration of patient-specific factors including cost, accessibility and toxicity This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium
Prostate Cancer Treatment Challenge: Which Drugs to Use First Triplet therapy with docetaxel plus an ARPI and ADT has become a widely accepted first-line treatment for patients with high-volume synchronous mHSPC—especially for those with visceral