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Androgen Receptor Pathway Inhibitors | Prostate Cancer Foundation These medicines are newer “second-generation” hormone treatments and are FDA-approved for patients with certain states of advanced prostate cancer: Metastatic castration-resistant prostate cancer (mCRPC) You may also hear them referred to as androgen receptor signaling inhibitors (ARSIs) or androgen receptor axis targeted agents (ARATs)
Androgen receptor pathway inhibitors, prostate cancer, and . . . - PubMed Prostate cancer is a disease of older adults that has undergone a significant therapeutic paradigm shift in the last decade with the emergence of novel androgen receptor pathway inhibitors (ARPis) One of the more commonly used ARPis is enzalutamide
Androgen receptor pathway inhibitors, prostate cancer, and older adults . . . Prostate cancer is a disease of older adults that has undergone a significant therapeutic paradigm shift in the last decade with the emergence of novel androgen receptor pathway inhibitors (ARPis) One of the more commonly used ARPis is enzalutamide
Overview of ARPIs in the Treatment of Prostate Cancer Comprehensive insights on ARPIs (androgen receptor pathway inhibitors) for the treatment of prostate cancer, highlighting what influences treatment decisions and safety profiles of the available APRIs
ARPI in Prostate Cancer: Current Progress - Biology Insights Androgen receptor pathway inhibitors (ARPIs) are categorized based on their mechanisms of action, targeting different aspects of androgen signaling to suppress prostate cancer progression These agents fall into three primary classes: nonsteroidal anti-androgens, steroidal anti-androgens, and androgen synthesis blockers
Most men with advanced prostate cancer benefit from new generation . . . The STOPCAP meta-analysis investigated the effects of three drugs within the androgen receptor pathway inhibitor class (ARPIs): enzalutamide, apalutamide and abiraterone These drugs work by preventing testosterone and other androgen hormones from attaching to androgen receptors on prostate cancer cells This interrupts prostate cancer growth
ARPIs May Improve Survival in Some With Prostate Cancer In patients with metastatic castration-resistant prostate cancer, researchers have found that androgen receptor pathway inhibitors (ARPIs) outperformed the standard of care, which improved responses to treatment and overall survival (OS; time a patient lives, regardless of disease status)
Addition of New Androgen Receptor Pathway Inhibitors to Docetaxel and . . . In recent years, significant changes have occurred in metastatic hormone-sensitive prostate cancer (mHSPC) management, where docetaxel and new androgen receptor pathway inhibitors (ARPI) have been shown to improve overall survival (OS) compared to