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Pathology Outlines - Atypical lobular hyperplasia In the differential of ALH and solid ADH immunohistochemistry can be very helpful, with ALH showing lack or attenuation of E-cadherin and cytoplasmic staining via p120 as shown above ADH in contrast has strong, diffuse E-cadherin staining and membranous staining via p120 Comment Here Reference: Atypical lobular hyperplasia (ALH)
Pathology Outlines - Lobular carcinoma in situ (LCIS) classic Distinction between ALH and LCIS is the percentage of the TDLU involved (> 50% in LCIS and < 50% in ALH) with acini that are filled and expanded to qualify as LCIS Some authors use LN terminology to denote the histologic overlap and frequent coexistence of ALH and LCIS (Cancer 1978;42:737)
Pathology Outlines - Atypical ductal hyperplasia Atypical ductal hyperplasia is an intraductal clonal epithelial cell proliferation with similar histologic features to (but insufficient involvement or volume for the diagnosis of) low grade ductal carcinoma in situ (DCIS)
Pathology Outlines - Angiolymphoid hyperplasia with eosinophilia Dermal based lesion with extension into the subcutaneous tissue Proliferation of vascular channels as nests and cords of endothelial cell proliferations with admixed lymphocytes, plasma cells and eosinophils, accompanied by hemorrhage and proliferation of thick and thin walled blood vessels (Dermatol Pract Concept 2018;8:28)
Pathology Outlines - E-cadherin E-cadherin is a transmembrane protein involved in cellular adhesion and polarity maintenance
Pathology Outlines - LCIS florid Majority arise in association with classic LCIS or atypical lobular hyperplasia (ALH) (Ann Diagn Pathol 2020;45:151481) Strong association with invasive lobular carcinoma, potentially as a direct precursor (Am J Surg Pathol 2019;43:399, Arch Med Res 2010;41:436, Ann Diagn Pathol 2020;45:151481, Ann Surg Oncol 2011;18:1845)
Pathology Outlines - LCIS pleomorphic Pleomorphic lobular carcinoma in situ (PLCIS) is a morphologic subtype of lobular carcinoma in situ (LCIS) composed of a noninvasive neoplastic proliferation of large dyscohesive cells with marked nuclear pleomorphism, > 4 times the size of a lymphocyte
Pathology Outlines - Radial scar complex sclerosing lesion Atypical hyperplasia (ADH, ALH) observed in 21 - 51% (Breast Cancer Res Treat 2008;107:371, Cancer 2003;97:345) In situ or invasive carcinoma may arise within or in association with radial scar complex sclerosing lesions