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GRANTS - ALZFORUM Please Note: We remove grant postings after 6 months If you would like your listing to be posted longer or taken down sooner, please contact us at grants@alzforum org
Troriluzole - ALZFORUM Background Troriluzole is a prodrug formulation of riluzole, a medication used to treat amyotrophic lateral sclerosis Following oral administration, aminopeptidases in the blood release riluzole from a tripeptide carrier Unlike riluzole, which must be taken twice a day on an empty stomach, this prodrug requires only once-daily dosing and is unaffected by food
APP NL-G-F Knock-in | ALZFORUM Summary Untangling the effects of elevated Aβ from those due to APP overexpression is a common challenge when interpreting the phenotypes of APP transgenic mice The APP NL-G-F model avoids potential artifacts introduced by APP overexpression by using a knock-in approach to express APP at wild-type levels and with appropriate cell-type and temporal specificity APP is not overexpressed, but
Troculeucel | ALZFORUM Background Troculeucel is an immunotherapy consisting of a patient’s own natural killer cells that have been isolated, expanded in the lab, and re-infused The cells are not genetically modified No immunosuppression is required because the cells originate from each patient Troculeucel aims to replenish declining natural killer activity in people with Alzheimer’s disease
Tau (DA9) | ALZFORUM Alzforum does not sell or distribute antibodies Please contact the source to order or request antibodies
Dronabinol - ALZFORUM In trials, the most frequent side effects were euphoria, dizziness, sleepiness, nausea and vomiting, abnormal thinking, paranoia, and abdominal pain Risks of dronabinol in older people include delirium, sedation, seizures, blood pressure changes, and increased heart rate It has a low potential for abuse or dependence
APPPS1 - ALZFORUM Summary APPPS1 mice contain human transgenes for both APP bearing the Swedish mutation and PSEN1 containing an L166P mutation, both under the control of the Thy1 promoter In these mice, expression of the human APP transgene is approximately 3-fold higher than endogenous murine APP Human Aβ42 is preferentially generated over Aβ40, but levels of both increase with age In the brain, the
Arimoclomol | ALZFORUM Arimoclomol is a hydroxylamine derivative, one of a group of compounds that act as co-inducers of heat-shock protein expression In preclinical work, arimoclomol reduced symptoms and prolonged life in animal models of amyotrophic lateral sclerosis caused by SOD1, FUS, or valosin-containing protein mutation, as well as models of spinal muscular atrophy and NPC (Kieran et al , 2004; Pelaez et al