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Biologics for eosinophilic oesophagitis: a systematic review . . . Keywords: Eosinophilic esophagitis, eosinophil gastrointestinal diseases, biologic therapies, meta-analysis KEY MESSAGES We performed a meta-analysis using high-quality randomized controlled trials to confirm the clinical efficacy and safety of biologic therapies
Current state of biologics in treating eosinophilic esophagitis Eosinophilic esophagitis (EoE) is a chronic, allergen-mediated, eosinophil-predominant, type 2 inflammatory disease that progresses to fibrostenosis of the esophagus if left untreated This review focuses on biologics therapy in EoE
Biologics in the Treatment of Eosinophilic Esophagitis: Ready . . . Eosinophilic esophagitis (EoE) is a chronic disease mediated by environmental allergens and type 2 immune inflammation, which causes significant symptoms including dysphagia and food impaction 1,2 The incidence and prevalence of EoE are rising and untreated disease can lead to significant esophageal stenosis 2,3 Standard treatments include proton-pump inhibitors (PPIs), swallowed topical
Biologics in eosinophilic esophagitis - PubMed Abstract Purpose of review: Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the oesophagus whose incidence is on the rise Despite maximal use of guideline-based therapies including food elimination diets and steroids, many patients remain symptomatic This review serves to summarize safety and efficacy of monoclonal antibodies in treatment of EoE
Biologics in Eosinophilic Esophagitis — Ready for Prime Time? Eosinophilic esophagitis is an immune-mediated, chronic, inflammatory disease of the esophagus that was first recognized as a distinct entity less than three decades ago 1 The immunopathogenesis of
Eosinophilic esophagitis in adults: expanding therapeutic . . . Eosinophilic esophagitis (EoE) is part of the broader spectrum of primary eosinophilic gastrointestinal disorders—conditions characterized by increased eosinophilic infiltration in various segments of the gastrointestinal tract Despite increasing research attention, the pathophysiology of EoE remains only partially understood
10 Biologics for Treating Eosinophilic Esophagitis in Adults Biologics have emerged as a promising treatment option for adults with eosinophilic esophagitis (EOE), a chronic allergic inflammatory condition of the esophagus These medications work by targeting specific components of the immune system to reduce inflammation and symptoms associated with EOE
Biologics in eosinophilic gastrointestinal diseases Biologics in Eosinophilic Esophagitis Multiple studies of biologics for use in EoE have either been published in full manuscript form, presented in abstract form or have had initial results released, or are ongoing (Table 1)
Current and Emerging Therapies for Eosinophilic Esophagitis . . . Eosinophilic esophagitis (EoE) can be treated using a wide range of therapies, including dietary elimination, acid suppression, steroids, and more recently, biologic medications In this review, the authors aim to provide an overall review of EoE therapeutics both in use and in clinical development in pediatrics and adults 2