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- Nigro Protocol for Anal Cancer Treatment
Nigro Protocol consists of radiation therapy combined with 5-FU and mitomycin-C It is the standard first step of treatment for most people diagnosed with anal cancer in stages I through III, specifically for squamous cell carcinoma
- What is the Nigro protocol (chemoradiation therapy regimen) for . . .
The protocol typically consists of 5-fluorouracil (5-FU) administered as a continuous infusion at 1,000 mg m² day for 4 days during weeks 1 and 5 of radiation therapy, along with mitomycin C given as a bolus injection at 10-15 mg m² on day 1 of treatment
- Nigro protocol - Wikipedia
A 2024 systematic review of the literature found that chemoradiation with 5-FU and mitomycin C, as used in the Nigro Protocol, improves outcomes like colostomy-free survival in anal cancer patients compared to alternatives like cisplatin
- From Guidelines to Practice: Clinical Perspectives on Mitomycin-Based . . .
The treatment evolution for anal cancer began in the 1970s with the Nigro regimen, combining 5-fluorouracil and mitomycin with radiation therapy, which demonstrated the potential to spare surgery through chemoradiation alone
- Nigro protocol - grokipedia. com
The Nigro protocol is a chemoradiotherapy regimen for squamous cell carcinoma of the anal canal, originally consisting of external beam radiation therapy at 30 Gy combined with continuous intravenous 5-fluorouracil (1000 mg m² day for days 1–4 and 29–32) and mitomycin-C (15 mg m² bolus on day 1) 51:103 0 co;2-l) Developed by Norman D Nigro and colleagues at Wayne State University in the
- Fluorouracil (5-FU) and Mitomycin with Radiation Therapy
People who do not produce any DPD enzyme are at increased risk of sudden side effects that come on early during treatment with fluorouracil (5-FU) and can be serious, and sometimes lead to death
- Anal Carcinoma Therapy: Can We Improve on 5-Fluorouracil Mitomycin . . .
In 1983, Nigro et al 6 showed that a complete pathologic response could be achieved with the com-bination of mitomycin C (MMC), 5-fluorouracil (5-FU), and 30 Gy of pelvic radiotherapy before surgi-cal resection
- Mitomycin-C and Fluorouracil (anal) - SWAG Cancer Alliance
Administration Mitomycin C is administered by IV bolus via fast running infusion of sodium chloride 0 9% Fluorouracil is to be started at least 2 hours prior to first fraction of radiotherapy
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