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- Modified CIM test as a useful tool to detect carbapenemase activity . . .
Phenotypic methods defined by the Clinical and Laboratory Standards Institute (CLSI) to detect carbapenemase producers include the modified Hodge test (removed from the M100-S28 in 2018; CLSI), the Carba NP test, and most recently the modified carbapenem inactivation method (mCIM) (Cunningham et al 2017; Pierce et al 2017)
- Modified Carbapenem Inactivation Method for Phenotypic Detection of . . .
Here we describe a two-stage evaluation of a modified carbapenem inactivation method (mCIM), in which tryptic soy broth was substituted for water during the inactivation step and the length of this incubation was extended
- Carbapenemase Testing - University of Utah
Modified Carbapenem Inactivation Method - mCIM Purpose: To test for suspected carbapenemase production in Enterobacteriaceae and Pseudomonas aeruginosa In laboratories using carbapenem breakpoints from M100 S20 (2010) Enterobacteriaceae ex: imipenem or meropenem MICs 2-4 μg mL, or ertapenem MIC 2 μg mL Infection control or epidemiological
- Combination of modified carbapenem inactivation method (mCIM) and EDTA . . .
In this study, we aimed to evaluate the phenotypic methods, Modified Hodge test (MHT), modified carbapenem inactivation method (mCIM), and EDTA-CIM (eCIM) for the detection of carbapenemase-producing Enterobacteriaceae (CPE)
- Opening the Black Box of Phenotypic Carbapenemase Detection
The Clinical and Laboratory Standards Institute (CLSI) M100 document recommends use of molecular, carbapenem hydrolysis (Carba-NP), or phenotypic (mCIM eCIM) assays to detect enzymes that degrade these drugs (carbapenemases) for epidemiologic purposes
- Phenotypic Methods for the Detection of Carbapenemases
Modified Hodge test (MHT) The modified Hodge test (MHT) is probably the most widely used approach for carbapenemase detection It involves streaking of a clinical isolate in a line away from an ertapenem or meropenem disk which placed previously on an agar plate inoculated with a lawn of a carbapenem-susceptible Escherichia coli strain
- Utilization of the Modified Carbapenem Inactivation Method (mCIM) to . . .
This report describes the results of using the modified carbapenem inactivation method (mCIM) at the Nebraska Public Health Laboratory (NPHL) as a cost-effective, rapid, and reliable method to screen carbapenem-resistant Enterobacterales (CRE) for carbapenemase production
- mCIM test as a reliable assay for the detection of CRE in the . . . - PubMed
These findings indicate that the mCIM test is a reliable and simple assay for detecting the activity of carbapenemase in Enterobacterales, especially in resource-limited laboratories Keywords: carbapenem resistant Enterobacterales; gulf region prevalence; modified carbapenem inactivation method
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