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- Trialists Grapple with How to Outsmart TREM2 | ALZFORUM
Series - AD PD™ 2025: Advances in Science Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to Harness AI for Alzheimer’s Research Part 3 of 15: Moving Target: New Biology Casts TREM2 as a Shifty Mark Part 4 of 15: TREM2: A Chill Pill for Neurons? Part 5 of 15: Trialists Grapple with How to Outsmart
- Moving Target: New Biology Casts TREM2 as a Shifty Mark
Series - AD PD™ 2025: Advances in Science Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to Harness AI for Alzheimer’s Research Part 3 of 15: Moving Target: New Biology Casts TREM2 as a Shifty Mark Part 4 of 15: TREM2: A Chill Pill for Neurons? Part 5 of 15: Trialists Grapple with How to Outsmart
- TREM2 | ALZFORUM
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor of the innate immune system expressed on microglia, macrophages, dendritic cells, and osteoclasts TREM2 is a member of the immunoglobulin superfamily Endogenous ligands of this receptor are unknown but when triggered, it signals through the transmembrane adapter protein TYROBP DAP12 to activate phagocytosis of pathogens
- Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
TREM2 antibody sports transferrin receptor binding domain to ease entry into brain It activated microglia and boosted brain glucose metabolism The antibody is in a first Phase 1 trial
- Is Transgelin-2 a ‘Receptor’ for Soluble TREM2? | ALZFORUM
Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of intense investigation Now, researchers led by Zhentao Zhang, Renmin Hospital of Wuhan University, China, say the soluble ectodomain
- TREM2 Cleavage Site Pinpointed: A Gateway to New Therapies?
TREM2 binds anionic lipids released during neuronal and glial damage It supports microglial metabolism and it promotes the migration, cytokine release, phagocytosis, proliferation, and survival of the cells (Aug 2017 news; Feb 2015 news) Evidence suggests that TREM2 spurs microglia to form a neuroprotective barrier around amyloid plaques and to clear Aβ (May 2016 news; Jul 2016 news
- TREM2 - ALZFORUM
TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival TREM2 variants cause Nasu-Hakola disease (NHD), a rare autosomal recessive early-onset dementia, and may modify the risk of developing Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis
- TREM2 rs9357347 - ALZFORUM
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression
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