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- Liquid-Liquid Phase Separation in Chromatin - PubMed
Recent studies invoke liquid-liquid phase separation (LLPS) of proteins and RNAs in the establishment of chromatin activity patterns At the same time, the folding of chromatin in the nucleus can drive genome partitioning into spatially distinct domains
- Organization of Chromatin by Intrinsic and Regulated Phase Separation
We demonstrate that reconstituted chromatin undergoes histone tail-driven liquid-liquid phase separation (LLPS) in physiologic salt and when microinjected into cell nuclei, producing dense and dynamic droplets
- Liquid-liquid phase separation (LLPS) in DNA and chromatin systems from . . .
Following that, we discuss and illustrate the similarities of such macroscopic phase separation with the general behaviour of LLPS droplet formation by associative phase separation for DNA-protein systems, including chromatin; we also note cases of segregative association
- Chromatin Liquid-Liquid Phase Separation (LLPS) Is Regulated by Ionic . . .
Several recent studies suggested that chromatin undergoes liquid-liquid phase separation (LLPS) in vitro and also in vivo; yet, controversial conclusions about the nature of chromatin LLPS were also observed from the in vitro studies
- Phase Separation: A New Dimension to . . . - Wiley Online Library
Graphical Abstract Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions The low-complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates
- Organization of Chromatin by Intrinsic and Regulated Phase Separation
We demonstrate that reconstituted chromatin undergoes histone tail-driven liquid-liquid phase separation (LLPS) in physiologic salt and when microinjected into cell nuclei, producing dense and dynamic droplets
- Phase separated condensates of ATRX regulate neural progenitor . . . - Nature
Tomooka et al demonstrate that phase-separated ATRX condensates play an essential role in maintaining human neural progenitor identity through chromatin regulation and transcriptional control
- Getting in phase- DNA damage repair mechanisms and liquid-liquid phase . . .
Chromatin integrity involves the highly orchestrated activity of genetic and epigenetic factors remodeling the chromatin landscape, including chromatin interacting proteins, histone modifying enzymes and DNA repair enzymes
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