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- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease In the February 10 Nature Medicine, researchers led by Thomas Karikari, University of Pittsburgh, unveil their
- LY3954068 | ALZFORUM
LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau No information is available about the makeup of LY3954068
- Tau (PHF-1) | ALZFORUM
Recognizes tau doubly phosphorylated at serines 396 and 404 Immunoreactivity seen in Alzheimer's disease and other tauopathies but not controls Used to assess the progression of tau pathology in human disease and in the brains of animal models of tauopathy Validated in knockout and cell-based assays
- A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter
With T cells sidelined in these CD8 knockouts, tau pathology went on the offensive By 30 weeks of age, phospho-tau had spread deeper into the brain than in CD8-intact controls (image below) Michal Schwartz of the Weizmann Institute of Science in Rehovot, Israel, noted that these findings run counter to conventional thinking
- Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of neurofibrillary tangles, with postmortem plaque and tangle load, and with cognitive test scores better than plasma total tau and neurofilament light, the currently available blood markers of neurodegeneration
- Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
Tau, Incorporated A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains The degree of incorporation of each mutant into the growing fibrils (middle) is measured via FRET (right) [Courtesy of Vaquer-Alicea et al , Science Advances
- JNJ-64042056 | ALZFORUM
In both wild-type C57BL 6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies specifically directed against phosphorylated tau, rather than non-phosphorylated tau The resulting antibodies were reported to bind neurofibrillary tangles in mouse brain tissue sections and to reduce soluble tau as
- Widely Used Tau Seeding Assay Challenged - ALZFORUM
Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for Neurodegenerative Diseases, Bonn, question whether a widely used
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