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  • New therapies for postural hypotension - PMC
    For example, patients with severe neuropathy of the peripheral autonomic system can have a pressor response to phenylephrine eye drops and a paradoxical increase in blood pressure (BP) from the antihypertensive clonidine 1 Currently, the only approved therapy for postural hypotension in the USA is midodrine, an α 1 agonist
  • Phenylephrine Therapy to Treat Refractory Orthostatic Hypotension in a . . .
    Orthostatic hypotension (OH) is characterized by abnormal decrease in systolic blood pressure (BP) greater than 20 mm Hg or diastolic BP greater than 10 mm Hg when standing from a supine or sitting position
  • Pharmacological treatments of postural hypotension - PMC
    Phenylephrine is another direct alpha‐1 adrenoreceptor agonist used in the treatment of orthostatic hypotension (Jordan 1998) Droxidopa is an L‐norepinephrine precursor that results in an increase in circulating norepinephrine levels and a corresponding increase in blood pressure (Freeman 1999; Gibbons 2005b)
  • Treatment of orthostatic and postprandial hypotension
    Orthostatic hypotension (OH) describes a reduction in systolic blood pressure of at least 20 mmHg or a reduction in diastolic blood pressure of at least 10 mmHg, usually within the first three minutes of standing or head-up tilt on a tilt table
  • Pharmacologic treatment of orthostatic hypotension - PMC
    This explains the profound drop in BP in response to venous pooling induced by standing (orthostatic hypotension) or digestion (postprandial hypotension), but also the dramatic increase in BP observed after seemingly trivial stimuli (e g , the water pressor reflex (Shannon et al , 2002))
  • Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive . . .
    Several cardiovascular and psychoactive medications may alter the blood pressure response to standing, leading to drug-related orthostatic hypotension This narrative review provides an overview on cardiovascular and non-cardiovascular medications potentially impairing orthostatic blood pressure
  • Evaluation and Management of Orthostatic Hypotension | AAFP
    Evaluation of suspected orthostatic hypotension begins by identifying reversible causes and underlying associated medical conditions
  • Phenylephrine: Low Blood Pressure Uses, Warnings, Side . . . - MedicineNet
    Phenylephrine is a medication used in clinical settings for the treatment of low blood pressure (hypotension) resulting primarily from blood vessel dilation (vasodilation) during anesthesia Phenylephrine is administered intravenously to increase blood pressure back to normal levels, after withdrawal of anesthesia




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