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NARRATIVE High levels of circulating androgens can negatively affect neuroendocrine reproductive hormone levels in females, yet the mechanisms and target cells by which androgens achieve these effects remain unknown Indeed, hyperandrogenemia from exogenous androgens is a fundamental aspect of reproductive disruptions seen in transgender men (genetic females) and other clinical conditions, but
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PROJECT SUMMARY ABSTRACT Tau protein is an attractive AD therapeutic target because the amount and anatomical distribution of insoluble tau at autopsy is strongly correlated with the symptoms and severity of disease during life Multiple tau therapies are now in clinical trials for AD, with many new agents entering the clinic New approaches to accelerating their clinical development are
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Quantifying TF-DNA binding, including locations, distributions, and binding mechanism is an important first step toward the understanding of gene regulatory machinery In this proposal, we will develop an atomic force microscope (AFM)-based single-molecule imaging method for the detection and quantification of TF-DNA binding The new technique brings the methods of mathematics and statistics
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