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- PDB-101: Molecule of the Month: SARS-CoV-2 Spike
Spike protein from SARS-CoV, with one receptor binding domain (RBD) in the up position, and a closed conformation of the SARS-CoV-2 spike The S1 fragment is shown in magenta and the S2 fragment in red, with glycosylation in lighter shades
- 5DO2: Complex structure of MERS-RBD bound with 4C2 antibody - RCSB PDB
Both mAbs potently bind to MERS-RBD and block virus entry in vitro with high efficacy We further investigated their mechanisms of neutralization by crystallizing the complex between the Fab fragments and the RBD, and solved the structure of the 4C2 Fab MERS-RBD complex
- RCSB PDB - 6M0J: Crystal structure of SARS-CoV-2 spike receptor-binding . . .
Here, to better understand the initial step of infection at an atomic level, we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor ACE2
- RCSB PDB - 8Z27: The structure of TGEV RBD and dog APN complex
We identified R325 of dAPN as an important residue in the PDCoV RBD-dAPN interaction, and found the central role of Q746 and T749 in dAPN in the interaction with the TGEV RBD
- RCSB PDB - 8Q93: Crystal structure of the SARS-COV-2 RBD with . . .
We have previously developed highly potent single-domain (VHH) antibodies, also known as nanobodies, that target the Receptor Binding Domain (RBD) of the SARS-CoV-2 Spike protein and neutralize the Wuhan strain of the virus
- RCSB PDB - 8ZER: Crystal structure of the complex of Wuhan SARS-CoV-2 . . .
Here we report on the successful crystal structure determination of the RBD:P2C5 complex at 3 1 Å, which revealed the intricate protein-protein interface, sterically occluding full ACE2 receptor binding by the P2C5-neutralized RBD
- RCSB PDB - 9B4U: Crystal structure of p110alpha-RBD covalently bound to . . .
Crystal structure of p110alpha-RBD covalently bound to a breaker compound BBO-10203 via Cys242
- RCSB PDB - 9IU1: Structure of SARS-CoV-2 JN. 1 spike RBD in complex with . . .
The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation
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