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- Pathology Outlines - Stains CD markers
Immunostains, routine stains and CD markers at PathologyOutlines com
- Pathology Outlines - Adenoid cystic carcinoma
Typically p63 positive p40 negative, whereas adenoid cystic carcinoma is typically positive for both p63 and p40 (Am J Surg Pathol 2014;38:257) HPV related multiphenotypic sinonasal carcinoma: Also can affect sinonasal tract and show similar morphology and expression May have surface dysplasia Positive for high risk HPV; negative for MYB-NFIB
- Pathology Outlines - Squamous cell carcinoma
C p40 is the stain of choice for the identification of squamous cell carcinoma and will help demonstrate squamous differentiation Answers A and B are incorrect because while CK7 and CK5 6 would also both be positive in this lesion, they would not prove squamous differentiation, as they are positive in the majority of lung carcinomas
- Pathology Outlines - Biopsies
The tumor cells show variable p40 reactivity and are negative for both TTF1 and mucicarmine What is the best designation for this tumor? Non-small cell carcinoma, favor adenocarcinoma Non-small cell carcinoma, favor squamous cell carcinoma Non-small cell carcinoma, not otherwise specified Squamous cell carcinoma Squamous cell carcinoma
- Pathology Outlines - NUT carcinoma
NUT carcinoma (see comment) Comment: Immunostains show that the tumor cells are positive for AE1 AE3, p40 and NUT and negative for CD99 and synaptophysin with intact SMARCB1 (INI1), supporting the above diagnosis NUT carcinoma is a rare, highly aggressive malignancy that is defined by translocations involving the NUTM1 gene
- Pathology Outlines - Nasopharyngeal carcinoma
Nasal cavity, paranasal sinuses, nasopharynx - Nasopharyngeal carcinoma - general
- Pathology Outlines - Basaloid squamous cell carcinoma
Practice answer #2 B The most likely diagnosis is basaloid squamous cell carcinoma The tumor cells only show 1 component and are diffusely positive for p40 and p63, making adenoid cystic carcinoma less likely The tumor cells show eosinophilic cytoplasm with negative synaptophysin, making small cell carcinoma less likely
- Pathology Outlines - Small cell carcinoma
Positive for p40 and high molecular weight keratins, negative neuroendocrine markers (CD56, synaptophysin, chromogranin) Lung adenocarcinoma, poorly differentiated: Negative for neuroendocrine markers, diffuse strong CK7 Atypical carcinoid tumor: More prominent nucleoli, organoid growth pattern Large cell neuroendocrine carcinoma:
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