- Sigvotatug vedotin | Pfizer Oncology Development Website
Sigvotatug vedotin is an investigational antibody-drug conjugate composed of 3 components: a monoclonal antibody directed to IB6 (integrin beta-6), a microtubule-disrupting agent MMAE (monomethyl auristatin E), and a protease-cleavable mc-vc (maleimidocaproyl-valine-citrulline) linker that covalently attaches MMAE to the antibody, which enables preferential release of MMAE within target cells1
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