The actions of exogenous leucine on mTOR signalling and amino . . . It was important to determine whether leucine could mediate mTOR-related signalling via activation of the putative regulator, hVps34, and amino acid transporters The present work demonstrates the ability of the BCAA member, leucine, to independently stimulate mTOR signalling in an experimental model of human skeletal muscle
Role of Leucine in the Regulation of mTOR by Amino Acids . . . We proposed that freshly isolated adipocytes may activate mTOR by an entirely different mechanism that does not rely on detection of the t-RNA charging state or t-RNA synthetase activity (Lynch et al 2000) The evidence for this is as follows
Leucine and mTORC1: a complex relationship | American Journal . . . In this review, we have summarized how leucine levels play a particularly important role in protein turnover, where intracellular leucine modulates mTORC1 signaling via multiple nutrient-sensing pathways as well as regulating the proteasome via a yet unknown mTORC1-independent mechanism
Leucine-Enriched Nutrients and the Regulation of mTOR . . . The anabolic actions of leucine and insulin appear to activate independent intracellular signalling pathways which converge at the mammalian target of rapamycin (mTOR) and eventually affect translation initiation and elongation
The actions of exogenous leucine on mTOR signalling and amino . . . mTOR signalling is transiently activated by leucine within human myotubes independently of insulin stimulation While this occurred in the absence of changes in gene expression of amino acid transporters, protein expression of hVps34 increased