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- KRAS - Wikipedia
KRAS acts as a molecular on off switch, using protein dynamics Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase
- Targeting KRAS mutations: orchestrating cancer evolution and . . .
Activating KRAS mutations are highly relevant to various cancers, and KRAS is the most frequently altered oncogenic protein in solid tumors While historically considered undruggable, two KRAS
- What’s new in KRAS mutation research? - MD Anderson Cancer Center
The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers
- KRAS gene: MedlinePlus Genetics
The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS MAPK pathway Learn about this gene and related health conditions
- KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic . . .
Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of KRAS has been considered as being implausible to target for decades
- KRAS Oncoprotein Signaling in Cancer - The New England Journal of Medicine
Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients
- KRAS mutations and lung cancer: Treatment and outlook
Changes in the KRAS gene can affect how lung cancer develops, as well as its treatment and survival rates Learn more here
- KRAS Mutations: Their Role in Cancer and Targeted Therapy
The KRAS gene belongs to a class of genes known as oncogenes, which can transform normal cells into cancerous ones when mutated These mutations can also cause chromatin rearrangements within cells, reverting tissue cells to an early developmental or “stem-like” state, initiating tumor formation
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