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- Glucuronidation - Wikipedia
The human body uses glucuronidation to make a large variety of substances more water-soluble, and, in this way, allow for their subsequent elimination from the body through urine or feces (via bile from the liver) Hormones are glucuronidated to allow for easier transport around the body
- Glucuronidation: Driving Factors and Their Impact on . . .
Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters
- Glucuronidation - an overview | ScienceDirect Topics
Glucuronidation is a process where glucose is used for conjugation, playing a significant role in endogenous and xenobiotic metabolism by forming glucuronides that are excreted in bile and urine
- Glucuronidation: Detox, Balance Hormones, Genes
Glucuronidation is an important detoxification reaction that inactivates and detoxifies estrogens, hormones, neurotransmitters, drugs, mold toxins, and cancer-causing toxins In this post, we’ll explain glucuronidation and factors that increase or decrease it
- Glucuronidation – An ABC of PK PD
Glucuronidation A conjugation reaction catalysed by a glucuronosyl transferase enzyme wherein a sugar (glucuronic acid) molecule is attached to a drug or to a phase I metabolite to render the conjugate more water-soluble and easier to eliminate in the urine or faeces
- Glucuronidation process
The human body uses glucuronidation to make a large variety of substances more water-soluble, and, in this way, allow for their subsequent elimination from the body through urine or feces (via bile from the liver)
- Glucuronidation | The Medicinal Chemists Guide to Solving . . .
Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity
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