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- Imaging blood–brain barrier disruption in neuroinflammation . . .
To overcome these difficulties, there is ongoing research into the use of in vivo imaging techniques, such as dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) and arterial spin labeling MRI (ASL MRI), which may easily detect subtle changes in BBB permeability; however, similar changes are seen as a result of neuroinflammation
- Advances in Imaging Techniques of the Blood-brain Barrier and . . .
Conventional contrast-enhanced T1WI provides a gross qualitative assessment of BBB disruption, but this technique cannot determine the extent of BBB disruption [10] Now, DCE-MRI is the most widely used noninvasive imaging technique for assessing BBB disruption [10]
- In vivo methods for imaging blood–brain barrier function and . . .
These developments may help develop a more comprehensive understanding of disease-specific BBB pathology The techniques are limited in that they require a large (in the order of 1 g kg) injection of glucose, which may itself alter the distribution of transporters or osmotically increase the paracellular permeability at the BBB
- Blood–brain barrier breakdown in Alzheimer disease and other . . .
Here, Sweeney and colleagues focus on advanced neuroimaging evidence of blood–brain barrier (BBB) breakdown in several neurodegenerative disorders The role of the ageing cerebrovascular system
- Blood–Brain Barrier Disruption and Perivascular Spaces in . . .
Susceptibility-based (T 2 *-weighted) MRI techniques have also been proposed to capture BBB disruption by detecting leakage or deposition of iron-containing blood-derived substances 30 Although this is not a direct or specific measure of BBB integrity, it expectedly correlates with BBB disruption as assessed with DCE MRI 30
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