Estimating Creatinine Clearance in the Elderly - Medscape The MDRD and CKD-EPI equations estimate the GFR directly, whereas the Cockcroft-Gault equation estimates creatinine clearance (CrCl) While CrCl is the parameter most often used in clinical trials
Zometa Dose Reductions Required in Patients With Renal Impairment Dose reductions for patients with a creatinine clearance of 60 mL per minute or less are calculated to achieve a target area under the curve (AUC) equal to that of patients with a clearance of 75
Tool Predicts Allopurinol Dose to Meet Urate Target in Gout In patients with gout, a novel prediction tool that relies on weight and creatinine clearance successfully identified the dose of allopurinol required to achieve a serum urate (SU) level < 6 mg dL
Estimation of Creatinine Clearance in Morbidly Obese Patients The common use of the Cockcroft-Gault equation suggests that it will remain the method of choice for drug dosing in patients with renal impairment In contrast, the MDRD4 equation is likely to