- CCR2 - Wikipedia
Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase [5]
- CCR2 Gene - GeneCards | CCR2 Protein | CCR2 Antibody
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus Type 1 Among its related pathways are Class A 1 (Rhodopsin-like receptors) and GPCR downstream signalling
- Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver . . .
CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites
- Inhibition of the CCL2 receptor, CCR2, enhances tumor response to . . .
Inhibition or blockade of the CCL2 CCR2 signaling axis has thus been an area of interest for cancer therapy
- Preclinical Evaluation of Stx-0712, a CCR2 Cytotoxicity Targeting . . .
We have developed a CCR2 targeting Cytotoxicity Targeting Chimera (CCR2-CyTAC, STX-0712), which potently binds CCR2 on cells, and when combined with the CyTAC platform antibody, eliminates target cells via enhanced effector mediated killing
- Macrophage chemokine receptor CCR2 plays a crucial role in macrophage . . .
Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury Following injury, CCR2 + monocytes are recruited from peripheral blood to wound tissue, and direct the initiation and resolution of inflammation that is essential for tissue repair
- Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver . . .
CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites
- CCR2 CXCR6 enhances tumor infiltration and antitumor . . . - Springer
Abstract Chimeric antigen receptor T (CAR-T) cell therapy has shown promise in treating solid tumors, but the clinical success is often limited by insufficient tumor infiltration In this study, we sought to engineered two MSLN-targeted CAR-T cell variants, Intra2 and Intra6, expressing CCR2 and CXCR6, respectively, to improve their migration toward the tumor microenvironment Flow cytometry
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