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- Tackling immunosuppression by Neisseria gonorrhoeae to facilitate . . .
Here we modified two key immunomodulatory proteins of the gonococcus; RmpM, which can elicit ‘blocking antibodies’, and PorB, an outer membrane porin which contributes to immunosuppression As meningococcal PorB has adjuvant properties, we replaced gonococcal PorB with a meningococcal PorB
- Gonococcal PorB: a multifaceted modulator of host immune responses
gonococcal outer-membrane protein is PorB, an essential porin that facilitates ion exchange Importantly, gonococcal PorB has several immunomodulatory properties To subvert the innate immune response, PorB suppresses killing mechanisms of macrophages and neutrophils, and recruits negative regulators of complement to the gonococcal cell surface
- PorB: Its Structure and Role in Bacterial Membranes
PorB is a trimeric β-barrel protein embedded in the outer membrane of Neisseria species, facilitating selective permeability Its structure consists of 16 anti-parallel β-strands spanning the membrane, forming a pore-like channel
- Role of Neisseria meningitidis PorA and PorB Expression in . . .
Neisseria gonorrhoeae expresses a single porin, PorB Changes in porin expression or variant porins mediate antibiotic resistance in several Gram-negative bacteria, including N gonorrhoeae (7 – 10) In N meningitidis, the absence of PorB increases resistance to tetracycline and cefsulodin in vitro (11)
- Neisseria menindigitis PorB: From Structure to Function to Disease…
As a model system to understand how TLRs recognize outer membrane proteins, we used the interaction between the TLR1 2 heterodimer and the outer membrane protein PorB from Neisseria meningitides
- Gonococcal PorB: a multifaceted modulator of host immune responses
The essential gonococcal outer-membrane porin, PorB, manipulates the innate immune response via recruitment of negative regulators of the complement system, and by repressing the killing mechanisms of macrophages and neutrophils Gonococcal PorB in
- Gonococcal PorB: a multifaceted modulator of host immune responses
N gonorrhoeae promotes its survival by manipulating both innate and adaptive immune responses The most abundant gonococcal outer-membrane protein is PorB, an essential porin that facilitates ion exchange Importantly, gonococcal PorB has several immunomodulatory properties
- Structure-Function Studies of the Neisseria gonorrhoeae Major Outer . . .
PorB is a voltage-gated pore that mediates ion exchange between N gonorrhoeae and the environment and is essential for bacterial viability, likely due to its ability to allow nutrients access to the periplasm (1, 2)
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