- Brexpiprazole - ALZFORUM
Brexpiprazole is approved in the United States for the treatment of schizophrenia, and as an add-on therapy for depression It was the first treatment approved for agitation associated with dementia in patients with Alzheimer's disease In addition, it is being tested in people with bipolar and post-traumatic stress disorder
- Brexpiprazole Eases Agitation in People with AD; So Does Being in a . . .
Curiously, the benefit of brexpiprazole over placebo paled in comparison to the effect of merely participating in the trial, as agitation eased substantially in both the treatment and placebo groups This finding jibes with results of another agitation trial presented at the conference, which tested the anti-depressant mirtazapine in people with AD Though that drug worked no better than
- FDA Approves Rexulti for Agitation in Alzheimer’s | ALZFORUM
Brexpiprazole is a derivative of aripiprazole, aka Abilify, an atypical antipsychotic As a group, such drugs have a sketchy track record in treating agitation in AD, and their side effects had prompted the agency to issue “black box” warnings (Steinberg and Lyketsos, 2012)
- Efficacy and Safety of Brexpiprazole for the Treatment of . . . - ALZFORUM
Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials Am J Geriatr Psychiatry 2020 Apr;28 (4):383-400
- Safety assessment of Brexpiprazole: Real-world adverse event analysis . . .
Jiang Y, Zhou L, Shen Y, Zhou Q, Ji Y, Zhu H Safety assessment of Brexpiprazole: Real-world adverse event analysis from the FAERS database J Affect Disord 2024 Feb 1;346:223-229
- Brexpiprazole: A Balance of Risks and Benefits. | ALZFORUM
Hitt EM Brexpiprazole: A Balance of Risks and Benefits Sr Care Pharm 2025 Mar 1;40 (3):115-122 PubMed Recommends Please login to recommend the paper Make a Comment
- Brexpiprazole for the Treatment of Agitation in Alzheimer . . . - ALZFORUM
Lee D, Slomkowski M, Hefting N, Chen D, Larsen KG, Kohegyi E, Hobart M, Cummings JL, Grossberg GT Brexpiprazole for the Treatment of Agitation in Alzheimer Dementia: A Randomized Clinical Trial JAMA Neurol 2023 Dec 1;80 (12):1307-1316 PubMed
- Brexpiprazole-related tardive dystonia in a young patient with . . .
Ebina T, Iwamoto K, Ikeda M Brexpiprazole-related tardive dystonia in a young patient with schizophrenia: A case report Psychiatry Clin Neurosci 2024 May;78 (5):334-335
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