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- Centrosome Amplification and Tumorigenesis: Cause or Effect?
This chapter focuses on the mechanisms by which an increase in centrosome number might lead to an increase or decrease in tumour progression and the role of proteins that regulate centrosome number in driving tumorigenesis
- Centrosomes and cancer: balancing tumor-promoting and inhibitory roles
From simply considering supernumerary centrosomes as promoters of abnormal cell division in cancer, to the demonstra-tion using in vivo models that these abnormalities directly contribute to tumorigenesis, field the has come a long way
- Centrosome Amplification Is Sufficient to Promote Spontaneous . . .
Tumors arising from centrosome amplification exhibit frequent mitotic errors and possess complex karyotypes, recapitulating a common feature of human cancer Together, our data support a direct causal relationship among centrosome amplification, genomic instability, and tumor development
- Centrosome amplification arises before neoplasia and increases upon p53 . . .
Our work shows that centrosome amplification in human tumorigenesis can occur before transformation, being repressed by p53 These findings suggest centrosome amplification in humans can contribute to tumor initiation and progression
- Amplified centrosomes—more than just a threat | EMBO reports
In particular, increased centrosome numbers, or so-called centrosome amplification (CA), can interfere with the fidelity of chromosome segregation during mitosis and contribute to genetic instability, aneuploidy, and tumor progression
- Centrosome dysfunction: a link between senescence and tumor . . . - Nature
Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and or aneuploidy, resulting in human disorders such as aging and
- Centrosome amplification in cancer and cancer-associated human diseases
Accumulated evidence from genetically modified cell and animal models indicates that centrosome amplification (CA) can initiate tumorigenesis with metastatic potential and enhance cell invasion
- Centrosome Amplification and Tumorigenesis: Cause or Effect?
This chapter focuses on the mechanisms by which an increase in centrosome number might lead to an increase or decrease in tumour progression and the role of proteins that regulate centrosome number in driving tumorigenesis
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