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- Futility Analyses in Research Ethics - numberanalytics. com
A futility analysis is a statistical evaluation conducted during a clinical trial to assess the likelihood of achieving a statistically significant result Why are futility analyses important in research ethics?
- Guidance on interim analysis methods in clinical trials - PMC
We explain each of the following types of interim analyses: efficacy, futility, safety, and sample size re-estimation, and we provide the reader with reasoning, examples, and implications for each
- Futility in Clinical Trials | Research, Methods, Statistics | JAMA . . .
This JAMA Guide to Statistics and Methods discusses the early stopping of clinical trials for futility due to lack of evidence supporting the desired
- Interim analysis in randomized controlled trials: utility and use cases
Findings on interim monitoring help drive study conduct decisions Findings on interim analysis help drive study design considerations The term “interim analysis” in clinical trials has multiple meanings modifications, specifically those pertaining to the study sample size or recruitment targets
- Futility in Clinical Trials - McGraw Hill Medical
This JAMA Guide to Statistics and Methods discusses the early stopping of clinical trials for futility due to lack of evidence supporting the desired benefit, evidence of harm, or practical issues that make successful completion unlikely
- Futility in Research: When to Discontinue Observational Research | RTI . . .
Recognizing futility ensures efficient resource allocation and ethical, scientifically sound research efforts By conducting interim analyses and monitoring accumulating results, researchers can and should reveal futility and provide counsel on whether to develop remedies or stop the study
- Two-stage futility analysis in phase III adaptive trials with time-to . . .
We propose a two-stage futility analysis in phase III adaptive trials with a time-to-event endpoint to decide whether to continue enrollment or stop the trial completely in the early portion of the study without any requirement on minimum follow-up time This approach is appropriate if the proportional hazard assumption is valid
- Interim evaluation of efficacy or futility in group-sequential trials . . .
There are two fundamental approaches for the interim futility assessment, i e , based on: (1) the conditional power (Lan and Halperin, 1982; Lachin, 2005) and (2) futility boundaries using group-sequential methodology (DeMets and Ware, 1980, 1982; Whitehead et al , 2003)
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