|
- COX Inhibitors - StatPearls - NCBI Bookshelf
This program thoroughly explores the pivotal role of COX inhibitors in managing chronic pain syndromes across diverse disease spectrums As indispensable anti-inflammatory agents, COX inhibitors significantly contribute to alleviating pain associated with various conditions
- Non-steroidal anti-inflammatory drugs: recent advances in the use of . . .
Selective COX-2 inhibitors have been among the most used NSAIDs during the ongoing coronavirus 2019 pandemic because they reduce pain and protect against inflammation-related diseases In this framework, the mechanism of action of both COX isoforms (particularly COX-2) as inflammation mediators must be reviewed
- The role of COX-2 in acute pain and the use of selective COX-2 . . . - PubMed
This article provides an overview on the therapeutic use of selective COX-2 inhibitors for relief of acute pain, largely based on clinical trials in patients undergoing the surgical removal of impacted third molars, with focus on analgesic efficacy and the potential safety associated with their use compared to dual COX-1 COX-2 inhibitors
- Strategies in Pain Management: New and Potential Indications for COX-2 . . .
Specific inhibitors of type-2 cyclooxygenase (COX-2) such as celecoxib and rofecoxib were developed to provide the analgesic and anti-inflammatory properties of traditional, non-selective NSAIDs, while avoiding the gastrointestinal complications associated with the inhibition of Type-1 cyclooxygenase (COX-1) 5 The application of the COX-2
- Recent development on COX-2 inhibitors as promising anti-inflammatory . . .
As a crucial enzyme for catalyzing the synthesis of prostaglandins, cyclooxygenase-2 (COX-2) was identified as a promising target for inflammation treatment This review highlights the current progress of developing COX-2 inhibitors with various synthetic and natural structures as NSAIDs candidates 1 Introduction
- Role of COX-2 Inhibitors in the Evolution of Acute Pain Management
Cyclooxygenase (COX)-2-selective inhibitors (coxibs) offer the peripheral pain-relieving benefits of nonselective NSAIDs but with fewer adverse GI effects; they also may have a role in central sensitization
- COX-2 Inhibitors: What They Are, Uses Side Effects
COX-2 inhibitors are approved to treat mild-to-moderate pain and inflammation caused by: Osteoarthritis Rheumatoid arthritis Juvenile arthritis Ankylosing spondylitis Menstrual pain (dysmenorrhea) Familial adenomatous polyposis Short-term pain, such as from sports injuries
- Strategies in pain management: new and potential indications for COX-2 . . .
Here we consider the use of the coxibs in acute pain syndromes such as primary dysmenorrhea and the pain associated with dental extraction, as well as considering their application in chronic low back pain and cancer pain
|
|
|