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- Mechanism of Action of Amiodarone - pharmacyfreak. com
Amiodarone prolongs phase 3 repolarization of the cardiac action potential by blocking potassium channels, increasing the action potential duration and refractory period Inhibits fast inward sodium channels (Class I effect), reducing the rate of depolarization (phase 0)
- Amiodarone: Uses, Interactions, Mechanism of Action | DrugBank Online
After intravenous administration, amiodarone acts to relax smooth muscles that line vascular walls, decreases peripheral vascular resistance (afterload), and increases the cardiac index by a small amount
- Amiodarone - StatPearls - NCBI Bookshelf
Amiodarone belongs to the class III antiarrhythmic drugs Similar to other drugs in this class, the primary mechanism of amiodarone involves the inhibition of potassium rectifier currents responsible for repolarizing the heart during phase 3 of the cardiac action potential
- Amiodarone: What Is It, How Does It Work, What Is It Used For | Osmosis
As amiodarone can decrease excitability of the cardiac cell, it is considered quite a versatile medication How does amiodarone work? Amiodarone decreases the heart’s ability to respond to unwanted electrical stimuli, which—left unaddressed—may cause an irregular heartbeat
- Amiodarone • LITFL • CCC Pharmacology
Use is recommended in the new Australasian Resuscitation Guidelines – treatment for refractory VF and VT and in stable tachycardia algorithms Chris is an Intensivist and ECMO specialist at The Alfred ICU, where he is Deputy Director (Education)
- Amiodarone - Wikipedia
Amiodarone is commonly used to treat different types of abnormal heart rhythms, such as atrial arrhythmias (supraventricular arrhythmias) and ventricular arrhythmias [13]
- What is the mechanism of action of Amiodarone (antiarrhythmic medication)?
Inhibiting adrenergic stimulation (non-competitive alpha and beta blockade) This multifaceted mechanism of action makes amiodarone effective for various arrhythmias, including both supraventricular and ventricular arrhythmias
- Pharmacology of Amiodarone | Pharmacology Mentor
Amiodarone is a strong inhibitor of multiple CYP450 isoenzymes (CYP3A4, CYP2C9, CYP2D6) and P-glycoprotein Warfarin, dabigatran, other anticoagulants: Increased bleeding risk; monitor INR closely, reduce dose as needed
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