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- ALOX12B overexpression in the skin drives inflammasome Th17 . . . - bioRxiv
Here, we employed Gene expression meta-analysis and clinical validation to dissect the global architecture of immune dysregulation responsible for inflammatory conditions in the skin
- ARACHIDONATE 12-LIPOXYGENASE, R TYPE; ALOX12B - OMIM
Online Mendelian Inheritance in Man (OMIM) is a comprehensive, authoritative compendium of human genes and genetic phenotypes that is freely available and updated daily The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 15,000 genes
- ALOX12B - Wikipedia
The expression of Alox12b and Aloxe3 mRNA in mice parallels, and is proposed to be instrumental for, skin development in mice embryogenesis; the human orthologs of these genes, i e ALOX12B and ALOXE3, may have a similar role in humans
- Inflammation Related Genes And Facts | Bosterbio
See what Boster has to offer for the research of these genes by clicking the gene name links below and view a more detailed info card product listing for that gene
- Inflammasome Genes | InvivoGen
InvivoGen provides an expanding collection of full-length sequenced genes involved in inflammasomes Inflammasomes are multimeric protein complexes that are crucial for host defense against infection and response to endogenous danger signals
- Gene: ALOX12B (ENSG00000179477) - Summary - Homo_sapiens - GRCh37 . . .
About this gene This gene has 4 transcripts (splice variants), 103 orthologues, 5 paralogues and is associated with 5 phenotypes
- WikiGenes - Alox12b - arachidonate 12-lipoxygenase, 12R type
In humans, inflammatory skin disorders such as psoriasis are associated with accumulation in the skin of the unusual arachidonic acid metabolite 12R-hydroxyeicosatetraenoic acid (12R-HETE), a product of the enzyme 12R-lipoxygenase [1]
- ALOX12B overexpression in the skin drives inflammasome Th17 signaling . . .
Using such approaches, we identified a gene signature comprising of ALOX12B, which is significantly upregulated in psoriatic and atopic dermatitis patient skin samples, and correlates with increased levels of pathological IL-1β and Th17 responses
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