- Different Effects of SSRIs, Bupropion, and Trazodone on Mitochondrial . . .
Significant positive correlations were confirmed between complex I-linked respiration and the activities of individual ETC complexes MAO activity was inhibited by all tested antidepressants, with SSRIs causing a greater effect than trazodone and bupropion
- In vitro effects of antidepressants and mood-stabilizing drugs on cell . . .
The primary aim of this study was to investigate the effects of four drugs for treatment of depression (bupropion, fluoxetine, amitriptyline, and imipramine) and five drugs for bipolar disorder treatment (lithium, valproate, valpromide, lamotrigine, and carbamazepine) on cell energy metabolism
- Selective serotonin reuptake inhibitor use is associated with worse . . .
These findings suggest that the use of selective serotonin reuptake inhibitors may be associated with impaired breathing and worse nocturnal oxygen saturation in individuals with depressive disorders and sleep complaints, but this needs to be confirmed by prospective studies
- Antidepressants that increase mitochondrial energetics may . . . - Nature
While the specific mechanism of antidepressant associated increase of ETC activity is not fully understood, animal models suggest an upregulation of mitochondrial activity, including cellular
- In vitro inhibition of mitochondrial respiratory rate by antidepressants
Effects of psychotropic drugs on respiratory rate were measured in brain mitochondria Inhibitory effects of tianeptine, fluoxetine, amitriptyline and chlorpromazine were found Antidepressants, but not mood stabilizers, are potent partial inhibitors of respiration
- SSRIs and Their Impact on Cellular Respiration Explained | Course Hero
SSRIs primarily impact the Krebs cycle, also known as the citric acid cycle, in cellular respiration By inhibiting serotonin reuptake, SSRIs change neurotransmitter levels, which indirectly affects energy metabolism
- Psychiatric drugs impact mitochondrial function in brain and other . . .
Mitochondria have been linked to the etiology of schizophrenia (SZ) However, studies of mitochondria in SZ might be confounded by the effects of pharmacological treatment with antipsychotic drugs (APDs) and other common medications This review
- In vitro effects of antidepressants and mood-stabilizing drugs on cell . . .
Antidepressants such as amitriptyline, fluoxetine, carbamazepine cause cellular respiration disorders by inhibiting complexes Ӏ and П in the mitochondria (Cikánková et al , 2020)
|