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- Structure of Fungal Fatty Acid Synthase and Implications for . . . - AAAS
In fungi, acetyl primer and malonyl elongation substrates are loaded from coenzyme A (CoA) to ACP by acetyltransferase (AT) and malonyl palmitoyl transferase (MPT) and condensed to acetoacetyl-ACP in a decarboxylative reaction catalyzed by ketoacyl synthase (KS)
- Fatty acid synthesis and lipid metabolism in the obligate biotrophic fungus
In animals and fungi, fatty acid de novo synthesis is catalyzed by large cytosolic multidomain proteins (fatty acid synthase, FAS) Mammals contain a single FAS polypeptide of about 2500 amino acids (type I FAS)
- Direct structural analysis of a single acyl carrier protein domain in . . .
Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes In fungi, FAS forms a 2 6 MDa
- Molecular mechanisms in fungal fatty acid synthase (FAS) assembly - bioRxiv
34 The fungal fatty acid synthase (fFAS) multienzyme is a barrel-shaped 2 6 MDa complex comprising six 35 times eight catalytic domains Upon barrel-formation, up to several hundred kDa large polypeptides 36 intertwine to bury about 170,000 Å2 of protein surface Functional, regulatory and structural data as
- Production, Biosynthesis, and Commercial Applications of Fatty Acids . . .
Some typical oleaginous fungi including Galactomyces geotrichum, Thraustochytrids, Mortierella isabellina, and Mucor circinelloides, have been well studied for the ability to accumulate fatty acids with commercial application Here, we review recent progress toward fermentation, extraction, of fungal fatty acids
- Identification of Inhibitors of Fungal Fatty Acid Biosynthesis
Fungal fatty acid (FA) synthase and desaturase enzymes are essential for the growth and virulence of human fungal pathogens These enzymes are structurally distinct from their mammalian counterparts, making them attractive targets for antifungal development
- Deciphering and engineering the polyunsaturated fatty acid synthase . . .
In the desaturase elongase pathway, long-chain saturated fatty acids, such as palmitic acid or stearic acid, are first synthesized by fatty acid synthase (FAS) with acetyl-CoA as precursors and then catalyzed by a series of desaturases and elongases to form final PUFAs
- Fusing α and β subunits of the fungal fatty acid synthase leads to . . .
Most fungal fatty acid synthases assemble from two multidomain subunits, α and β, into a heterododecameric FAS complex It has been recently shown that the complex assembly occurs in a
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