- Propanephosphonic acid anhydride - Wikipedia
Propanephosphonic acid anhydride (PPAA, T3P) is the trimeric anhydride of n-propyl phosphonic acid It is a useful reagent for peptide synthesis reactions, where it activates the carboxylic acid partner for subsequent reaction with a primary or secondary amine
- Propylphosphonic anhydride | 68957-94-8 - ChemicalBook
General Description Propylphosphonic anhydride (T3P) is a reactive n -propyl phosphonic acid cyclic anhydride It is a mild and low toxic coupling agent used in peptide synthesis T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction
- Understanding T3P from start to finish
Curia is the owner of the original patented T3P process (US007829736B2) allowing pharma companies to produce propanephosphonic acid anhydride of a superior quality – free of any halogens and sulfur
- Propylphosphonic anhydride | C9H21O6P3 | CID 111923 - PubChem
T3P 1-Propanephosphonic anhydride 50% in THF n-propylphosphonic acid anhydride Propylphosphonic Anhydride (50% wt in Ethyl Acetate) 1-Propanephosphonic anhydride 50% in toluene 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide C9H21O6P3 Propylphosphonic Acid Anhydride (Cyclic Trimer) 1-Propanephosphonic Acid Anhydride (Cyclic Trimer)
- Propane-phosphonic Acid Anhydride – T3P® Reagent | Curia
Trusted by leading pharmaceutical companies, T3P ® reagent simplifies amide and peptide bond formations while supporting a range of transformations like nitrile formation, alcohol oxidation, and heterocycle synthesis
- Amine to Amide Mechanism - T3P - Common Organic Chemistry
A detailed mechanism illustrating the conversion of an amine to amide using propylphoshonic anhydride (T3P)
- Acid-Amine Coupling using T3P – Organic Synthesis
To a solution of acid (1 eq ), amine (1 eq ), and DIPEA or Et 3 N (3 eq) in CH 2 Cl 2 (10 Vol) at 0 °C is added T3P (50% in EtOAc, 2 eq) slowly over a period of 30 min
- Propylphosphonic anhydride (T3P - ScienceDirect
Propylphosphonic anhydride (T3P ®) has been demonstrated to be an efficient and mild reagent for the one-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids
|