- GSK-1482160 | P2X7 Modulator | MedChemExpress
GSK-1482160 1001389-72-5 GSK1482160 GSK 1482160 P2X Receptor P2XRs orally P2X7 receptors pro-inflammatory Il-1β peripheral inflammation Inhibitor inhibitor inhibit
- Characterization of 11C-GSK1482160 for Targeting the P2X7 . . . - PubMed
GSK1482160, a potent P2X7R antagonist, has high receptor affinity, high blood-brain barrier penetration, and the ability to be radiolabeled with 11 C We report the initial physical and biologic characterization of this novel ligand
- Gsk1482160 | C14H14ClF3N2O2 | CID 23649427 - PubChem
Gsk1482160 | C14H14ClF3N2O2 | CID 23649427 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety hazards toxicity information, supplier lists, and more
- Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 . . .
Here we report the synthesis of [11 C]GSK1482160 { (S)- N - (2-chloro-3- (trifluoromethyl)benzyl)-1- [11 C]methyl-5-oxopyrrolidine-2-carboxamide, [11 C] 3} as a new candidate PET agent for imaging of P2X 7 receptor
- Increased regional P2X7R uptake detected by [18F]GSK1482160 . . . - bioRxiv
MicroPET was performed using [18 F]GSK1482160 in widely used mouse models of Alzheimer’s disease (APP PS1, 5×FAD and 3×Tg), 4-repeat tauopathy (rTg4510) mice and age-matched wild-type mice
- GSK1482160 | P2X7 NAM | Probechem Biochemicals
GSK1482160, CAS 1001389-72-5, GSK-1482160, P2X7 NAM, GSK1482160 is an orally available allosteric P2X7 receptor negative allosteric modulator (NAM)
- Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a . . .
GSK1482160, a potent P2X7R antagonist, has high receptor affinity, high blood–brain barrier penetration, and the ability to be radiolabeled with 11C We report the initial physical and biologic characterization of this novel ligand
- Brain‐X - Wiley Online Library
Abstract This study aimed to evaluate [18F]GSK1482160 Positron emission tomography imaging for targeting P2X7R, a biomarker for neuroinflammation Studies of acute neuroinflammation in rodents and
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