Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous . . . We present an efficient late-stage C−H alkylation of heteroarenes using gaseous C1−C4 alkanes via hydrogen atom transfer (HAT) photocatalysis in flow This protocol enables scalable and sustainable diversification of drugs and natural products
Late-Stage C–H Functionalization of Azines - PMC While this process involves strongly acidic conditions that would not broadly apply to other azine-containing pharmaceutical candidates, it does show the major benefits of azine radical additions, many of which stem from the venerable Minisci reaction, 33 which has enabled drug developers to obtain a valuable analogue in a single step from a C