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- Digoxin – Pharmacokinetics - UNIL
Digoxin is well absorbed in the gastrointestinal intestinal tract, and there is no massive hepatic first pass effect Digoxin’s oral bioavailability remains usually high (70%-80%), even though considerable metabolism of digoxin within the gastrointestinal tract may occur in some patients by hydrolysis in the acidic environment of the stomach
- Digoxin - StatPearls - NCBI Bookshelf
Digoxin helps control ventricular response rates and improves cardiac output The key mechanisms include a positive inotropic effect that enhances myocardial contraction and AV node inhibition, which slows the heart rate by prolonging the AV node's refractory period
- Clinical pharmacokinetics of digoxin - PubMed
About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the small intestine The degree of binding to serum albumin is 20 to 30% Digoxin is extensively distributed in the tissues, as reflected by the large volume of distribution
- Pharmacokinetics of Digoxin: Interpreting Bioavailability - PMC
Three subjects were first given a digoxin tablet in the fasting state and subsequently received the same formulation in the fed state, to simulate a spurious oral bioavailability difference As expected, when measured by peak serum digoxin
- Pharmacokinetic Considerations for Digoxin in Older People
Digoxin is not strongly influenced by first pass metabolism or hepatic metabolism While no sig-nificant decrease occurs in phase II metabolism, there is a decrease in clearance of drugs metabolised by phase I path-ways [9]
- digoxin - PharmGKB
Only a small percentage of digoxin undergoes hepatic biotransformation to form metabolites 3-beta-digoxigenin, 3-keto-digoxigenin, and their glucuronide and sulfate conjugates
- Clinical Pharmacokinetics of Digoxin E. lisalo - Springer
Pharmacology, Turku University, Turku Summary About 70 to 80 % of an oral dose of digoxin is absorbed, mainl in the proximal part of the small intestine The degr e of binding to serum albumin is 20 to 30 % Digoxin is extensively· distributed in the tissues, as
- Building and evaluation of a PBPK model for digoxin in adults
The final digoxin model applies target-binding to the ATP1A2, transport by P-gp in various organs including gut, liver and kidney, an unspecific hepatic metabolic clearance and glomerular filtration
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